Connecticut Glycoscience Group

Mark W. Peczuh

Department of Chemistry - University of Connecticut

The major research theme in the Peczuh Group is the design and preparation of new carbohydrate compounds and the analysis of their interactions with proteins. Our investigation of protein-carbohydrate molecular recognition events is from the perspective of bioorganic chemistry. That is, we use a full complement of assay techniques and spectroscopies to investigate how incremental changes in carbohydrate structure can effect binding to target proteins. The synthesis and conformational analysis of unnatural carbohydrate structures is considered the foundation of our current and future research investigation.