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Rasmussen Laboratory
Department of Pharmaceutical Sciences
University of Connecticut

              The Rasmussen Laboratory at the University of Connecticut conducts basic and applied stem cell research that is designed to bring about advances in human health. The research methodologies utilized in the lab are drawn from stem cell science, epigenetics and chromatin dynamics, functional genomics, proteomics, molecular genetics, cell biology, and cell-based screening. Three major research objectives are under active investigation: (1) translational research involving cellular reprogramming to develop cell culture models for the study of human genetic disorders; (2) production and use of patient-matched iPS stem cells for use in personalized medicine research; (3) basic research on mechanisms involving epigenetics and chromatin to gain a deeper understanding of stem cell differentiation and cellular reprogramming.

              Long-range goals of the lab include the development of improved methods for the guided differentiation of human pluripotent cells to yield autologous transplantable cells with therapeutic properties. Another goal is to use patient-matched cells as a platform for personalized pharmacology and individualized determinations of treatment safety and efficacy. Dr. Rasmussen also investigates epigenetic function during mammalian gametogenesis, preimplantation development, and X chromosome inactivation.

BrightEScells

Mouse ES Cells

EScells

ES Cell Derivation and Differentiation

GFPEScells

GFP Transgenic Cells